Mono-N-Alkylation of Anthranylamides via Quinazolinones. An Efficient Synthesis of G5598, A Benzodiazepine Dione GpIIbIIIa Antagonist

DOI: 10.1016/S0040-4039(00)76773-6

Source and publish data:

Tetrahedron Letters p. 2113 - 2116 (1994)

Update date:2022-09-26

Topics:

Authors:

Webb, Robert R., II

Barker, Peter L.

Baier, Mark

Reynolds, Mark E.

Robarge, Kirk D.

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)76773-6

The mono-N-alkylation of an anthranylamide derivative via the reductive ring opening of a quinazolinone precursors, enables the synthesis of benzodiazepine dione derivative G5598, a potent inhibitor of the in vitro binding of GpIIbIIIa to fibrinogen.

Full text of DOI:10.1016/S0040-4039(00)76773-6

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