Chemical and Pharmaceutical Bulletin p. 1412 - 1414 (1996)
Update date:2022-09-26
Topics:
Satoh, Masato
Okamoto, Yoshinori
Koshio, Hiroyuki
Ohta, Mitsuaki
Nishida, Akito
Akuzawa, Shinobu
Miyata, Keiji
Mase, Toshiyasu
Semple, Graeme
A series of (3-substituted phenyl)urea analogues of the potent gastrin/cholecystokinin (CCK)-B receptor antagonist YM022 has been prepared. Structure activity relationship studies of this series suggested that a number of analogues retained good in vitro potency for gastrin/CCK-B receptor. In particular, the (3-amino substituted phenyl)urea derivatives (10-12) were more potent inhibitors of pentagastrin-induced gastric acid secretion in rats than YM022 on intraduodenal (i.d.) administration.
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Doi:10.1016/S0957-4166(03)00483-X
(2003)Doi:10.1055/s-2006-944222
(2006)Doi:10.1023/A:1023931428206
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(1976)Doi:10.1021/ja00439a074
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(1977)
