A New Synthesis of FPL 64176 and Analogues: The Discovery of Benzoylpyrrole Calcium Channel Activators with Low Nanomolar Potency

DOI: 10.1016/S0040-4020(01)91225-6

Source and publish data:

Tetrahedron p. 9089 - 9094 (1993)

Update date:2022-08-03

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Authors:

Baxter, Andrew J. G.

Teague, Simon

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Article abstract of DOI:10.1016/S0040-4020(01)91225-6

Heavy metal assisted halogen displacement on 2-halobenzoylpyrroles (2 and 3) leads to a simple synthesis of FPL 64176 (1) and a variety of analogues (4-10).The difluoro derivative (4), EC 50 1nM, and the amino linked analogue (7), EC 50 2.7nm, are present

Full text of DOI:10.1016/S0040-4020(01)91225-6

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