Double diastereodifferentiation in the hydroxylative Knovenagel condensation

Article abstract of DOI:10.1016/S0040-4039(00)61441-7

The stereoinduction in formation of γ-hydroxy-α,β-unsaturated enoates using chiral α-sulfinyl esters and chiral aldehydes is a function of the absolute stereochemistry of the sulfoxide, the substituent on the sulfoxide, and the amount of base.