3-Trifluoromethylthiophens from hexafluoroacetone

DOI: 10.1016/0022-1139(93)02906-U

Source and publish data:

Journal of Fluorine Chemistry p. 13 - 14 (1994)

Update date:2022-08-04

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Authors:

Burger, Klaus

Helmreich, Brigitte

Jendrewski, Oliver

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Article abstract of DOI:10.1016/0022-1139(93)02906-U

A one-pot procedure for the synthesis of 2-fluoro-3-trifluoromethyl-substituted thiophens 6 from 1-aryl-4,4-difluoro-3-trifluoromethylbut-3-en-1-one (3) and phosphorus pentasulfide is described.The fluorine atom at C-2 of compounds 6 undergoes nucleophili

Full text of DOI:10.1016/0022-1139(93)02906-U

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