Structural analogues of the antibiotic moenomycin a with a D-glucose-derived unit F

Article abstract of DOI:10.1016/S0040-4020(01)85066-3

Disaccharide derivative 1a is the smallest transglycosylase inhibiting compound known up to now. Structurally closely related compounds 11b and 19c have been synthesized. They do not inhibit the transglycosylase demonstrating the high specificity of the interaction between inhibitor 1a and the binding-site at the enzyme.