A Structure-Activity Relationship Study of Benzylic Modifications of 4--1H-imidazoles on α1- and α2-Adrenergic Receptors

DOI: 10.1021/jm00041a011

Source and publish data:

Journal of Medicinal Chemistry p. 2328 - 2333 (1994)

Update date:2022-08-02

Topics:

Authors:

Hong, Seoung-Soo

Romstedt, Karl J.

Feller, Dennis R.

Hsu, Fu-Lian

Cupps, Thomas L.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00041a011

The naphthalene analog of medetomidine (1), 4-<1-(1-naphthyl)ethyl>-1H-imidazole (2), is a highly potent, selective α₂-adrenoceptor agonist.We have initiated a structure-activity relationship study of the replacement of the methyl group on the

Full text of DOI:10.1021/jm00041a011

Products guided by the article

Product name:4-<(1-naphthyl)(trifluoromethyl)hydroxymethyl>-N-(triphenylmethyl)imidazole

Cas No:156833-35-1

R&D Labs maybe for 156833-35-1

KindChem Co.,Ltd,

Contact:+86-25-85281586

Address:13F,Bld2#,South of Longpan Road
QINGDAO ON-BILLION INDUSTRAIL CO.,LTD

website:http://www.obn.com.cn

Contact:+86-15005320811 +86-532-80681989

Address:F35 Parkson Mansion No.44-60 Zhongshan Rd.
Hangzhou Haiqiang Chemical Co.,Ltd.

Contact:+86-571-86960370

Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
SuZhou Ascepion Pharmaceuticals, Inc.(expird)

Contact:0512-86881668

Address:Building C,68Xingqing Road,Suzhou,China.
NEW FORTUNE INDUSTRIAL CO.,LTD.

website:http://newfortune.lookchem.com/

Contact:+86-25-8645-9456

Address:C4-105 GREEN ISLAND FLOWER TOWN

Relevant to this article

Regioselective Synthesis of Camptothecin

Doi:10.1016/S0040-4039(00)73254-0
(1994)
Empirical and theoretical insights into the structural features and host-guest chemistry of M₈L₄ tube architectures

Doi:10.1021/ja412964r
(2014)
Regiochemical Control of the Ring Opening of 1,2-Epoxides by Means of Chelating Processes. 7. Synthesis and Ring-Opening Reactions of cis- and trans-Oxides Derived from 2-(Benzyloxy)-3,6-dihydro-2H-pyran

Doi:10.1021/jo00094a025
(1994)
Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

Doi:10.1039/d0cc04861e
(2020)
Transition Metal Promoted Acetylene Isomerisation Reactions In Organic Synthesis

Doi:10.1016/S0040-4039(00)73103-0
(1994)
Magnetic nano-graphene oxide-supported molybdenum (Fe₃O₄/GO-Mo) as a green, efficient, and recyclable catalyst for synthesis of β-hydroxy hydroperoxides

Doi:10.1007/s00706-017-2092-8
(2018)

Article Doi