A Structure-Activity Relationship Study of Benzylic Modifications of 4--1H-imidazoles on α1- and α2-Adrenergic Receptors

DOI: 10.1021/jm00041a011

Source and publish data:

Journal of Medicinal Chemistry p. 2328 - 2333 (1994)

Update date:2022-08-02

Topics:

Authors:

Hong, Seoung-Soo

Romstedt, Karl J.

Feller, Dennis R.

Hsu, Fu-Lian

Cupps, Thomas L.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00041a011

The naphthalene analog of medetomidine (1), 4-<1-(1-naphthyl)ethyl>-1H-imidazole (2), is a highly potent, selective α₂-adrenoceptor agonist.We have initiated a structure-activity relationship study of the replacement of the methyl group on the

Full text of DOI:10.1021/jm00041a011

Products guided by the article

Product name:4-<(1-naphthyl)(trifluoromethyl)hydroxymethyl>-N-(triphenylmethyl)imidazole

Cas No:156833-35-1

R&D Labs maybe for 156833-35-1

Nanjing Norris Pharm Technology Co., Ltd.

Contact:+86-13901585132

Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China
Changzhou Welton Chemical Co., Ltd,

Contact:0086-519-85910828,85920537,85912897

Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.
Aqua Chem Industry Co., Ltd

Contact:+86-515-88356562

Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Tomo Pharma Chem Co., Limited

Contact:+86-158-05817090

Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Shanxi Sanwei Group Co.,Ltd

Contact:0086-357-6662688

Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province

Relevant to this article

Regioselective Synthesis of Camptothecin

Doi:10.1016/S0040-4039(00)73254-0
(1994)
Empirical and theoretical insights into the structural features and host-guest chemistry of M₈L₄ tube architectures

Doi:10.1021/ja412964r
(2014)
Regiochemical Control of the Ring Opening of 1,2-Epoxides by Means of Chelating Processes. 7. Synthesis and Ring-Opening Reactions of cis- and trans-Oxides Derived from 2-(Benzyloxy)-3,6-dihydro-2H-pyran

Doi:10.1021/jo00094a025
(1994)
Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

Doi:10.1039/d0cc04861e
(2020)
Transition Metal Promoted Acetylene Isomerisation Reactions In Organic Synthesis

Doi:10.1016/S0040-4039(00)73103-0
(1994)
Magnetic nano-graphene oxide-supported molybdenum (Fe₃O₄/GO-Mo) as a green, efficient, and recyclable catalyst for synthesis of β-hydroxy hydroperoxides

Doi:10.1007/s00706-017-2092-8
(2018)

Article Doi