Resolution of Δ2-Isoxazoline-5-carboxylates by a Protease from Aspergillus Oryzae Providing Masked Synthons for Enantiopure β-Aminoalcohols and Related Structures

Article abstract of DOI:10.1007/BF00811865

A series of racemic Δ²-isoxazolinecarboxylates have been synthesized and subjected to enzymatic hydrolysis by a protease from Aspergillus oryzae in a two-phase system.Out of these compounds only isoxazoline-5-carboxylates unsubstituted at C-4 w