Synthetic Communications p. 788 - 799 (2014)
Update date:2022-08-04
Topics:
Vana, Lubomir
Vrzal, Lukas
Dvorakova, Hana
Himl, Michal
Linhart, Igor
Direct arylation of adenine with fluoro-and chloronitrobenzenes leads to mixtures of N9 and N7 substituted adenines. After separation by column chromatography, the individual isomers can be efficiently hydrogenated on Pd to give the corresponding aminophenyladenines. A significant enhancement of the reaction rate by microwave irradiation was observed. This two-step procedure was found to be a feasible route to otherwise hardly available 7- aminophenyladenines. Correlation between calculated shielding constants and experimental values of chemical shifts in 13C and 15N NMR was used for assignment of the site of substitution. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
View MoreTIANJIN GST CHEMICAL TECHNOLOGY CO., LTD
Contact:+86-22-25210964
Address:Room. 208, No. -12-C, No. 13, Xinbei Road, Tanggu District, New Haixin Area, Tianjin City, China
Contact:86-571-86737118-8689
Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
RongCheng K&S Chemical Co.,Ltd
Contact:0631-7336369
Address:rongcheng ,shandong province china
SICHUAN TONGSHENG AMINOACID CO.LTD
website:http://www.aminoacid.cc
Contact:86-838-2274206/2850606
Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China
Anhui Xinyuan Technology Co.,Ltd
Contact:0086-559-3515800
Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China
Doi:10.1016/j.tet.2006.02.024
(2006)Doi:10.1007/BF00901753
(1960)Doi:10.1016/j.jorganchem.2005.11.028
(2006)Doi:10.1021/jo00181a043
(1984)Doi:10.1021/ol060288i
(2006)Doi:10.1021/jo00181a044
(1984)