Novel asymmetric desymmetrization of meso-1,2-diols via diastereoselective β-elimination of chiral α-arylsulfinyl acetals

Article abstract of DOI:10.1016/0040-4020(96)00294-3

Enantioselective desymmetrization of meso-1,2-diols was accomplished via diastereoselective C-O bond fission of acetals derived from various optically active β-ketosulfoxides with high diastereoselectivities. The substituent at the γ-position of the β-ketosulfoxide plays an important role in this cleavage.