Synthesis, conformational analysis, and biological-activity of the 1-α,25-dihydroxy-10,19-dihydrovitamin D3 isomers

DOI: 10.1006/bioo.1994.1013

Source and publish data:

Bioorganic Chemistry p. 150 - 171 (1994)

Update date:2022-08-04

Topics: Synthesis Biological Activity Conformational Analysis

Authors:

Sicinski

Deluca Deluca

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Article abstract of DOI:10.1006/bioo.1994.1013

The synthesis of the four 1α,25-dihydroxy-10,19-dihydrovitamin D₃ stereoisomers (8-11) is described starting from 25-hydroxyvitamin D₃(1c). Acetic acid-catalyzed cycloreversion of 1 α-hydroxylated 3,5-cyclovitamin D compound 14, prod

Full text of DOI:10.1006/bioo.1994.1013

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