Synthesis of Homochiral 3-Substituted Glutamic Acids and Prolines from Pyroglutamic Acid

Article abstract of DOI:10.1016/S0957-4166(00)86204-7

Efficient syntheses of (2S,3S)-methylproline (5a) and (2S,3R)-phenylproline (5b) are described, starting from the readily available pyroglutaminol derivatives 2a and 2b via conjugate 1,4=addition of organocuprates to 1.Catalytic hydrogenation of 3 from th