Synthesis of [3,5,5,5-2H4]-2-C-methyl-D-erythritol, a substrate designed for the elucidation of the mevalonate independent route for isoprenoid biosynthesis

Article abstract of DOI:10.1016/S0040-4039(99)01769-4

2-C-Methyl-D-erythritol 4-phosphate is a key intermediate in the mevalonate independent pathway for isoprenoid biosynthesis. In order to investigate the fate of the protons in this metabolic route, [3,5,5,5-²H₄]-2-C-methyl-D-erythrit