4,5-Dihydro-3-(methanesulfonamidophenyl)-1-phenyl-1H-2,4-benzodiazepines: A novel class III antiarrhythmic agents

DOI: 10.1021/jm00014a008

Source and publish data:

Journal of Medicinal Chemistry p. 2551 - 2556 (1995)

Update date:2022-07-30

Topics:

Authors:

Johnson Johnson

Silver Silver

Becker Becker

Birsner Birsner

Bohnet Bohnet

Briggs Briggs

Busacca Busacca

Canniff Canniff

Carabateas

Chadwick

D'Ambra D'Ambra

Dundore Dundore

Dung Dung

Ezrin Ezrin

Gorczyca

Habeeb Habeeb

Horan Horan

Krafte Krafte

Pilling Pilling

et al. et al.

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Article abstract of DOI:10.1021/jm00014a008

A series of 4,5-dihydro-3-[2-(methanesulfonamidophenyl)ethyl]-1-phenyl- 1H-2,4-benzodiazepines has been identified as potential antiarrhythmic agents that interact at the delayed rectifier myocardial potassium channels (I(Kr)) and prolong the ventricular

Full text of DOI:10.1021/jm00014a008

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Product name:(-)-4,5-Dihydro-4-methyl-1-(4-chlorophenyl)-3-methyl-1H-2,4-benzodiazepine

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