Synthesis and β-lactamase inhibitory activity of 6-[(1-heteroarylthioethyl-1,2,3-triazol-4-yl)methylene]- penam sulfones

Article abstract of DOI:10.7164/antibiotics.47.1030

The synthesis of β-lactamase inhibitory activity of a series or sodium 6-[(1-heteroarylthioethyl- 1,2,3-triazol-4-yl)methylene]penicillanate 1,1-dioxides are described. Their activity was compared with tazobactam and sulbactam. The Z-isomers were more act