Efficient synthesis of 3-aminothioacrylamides by iminoformylation of thioacetamides

Article abstract of DOI:10.1055/s-1994-25545

Heating substituted thioacetamides 1 with either trismorpholinomethane or with a mixture of triethyl orthoformate and a secondary amine gives high yields of synthetically versatile 3-aminothioacrylamides 4.