Development of a Model for the δ Opioid Receptor Pharmacophore. 1. Conformationally Restricted Tyr1 Replacements in the Cyclic δ Receptor Selective Tetrapeptide Tyr-cOH (JOM-13)

Article abstract of DOI:10.1021/jm00051a015

A series of analogues of the conformationally restricted δ opioid receptor selective tetrapeptide Tyr-cOH (JOM 13) was prepared in which the conformationally labile Tyr residue was replaced with several less flexible tyrosine analogues.Am