Pd(OAc)2-catalyzed aminocarbonylation of aryl iodides with aromatic or aliphatic amines in water

Article abstract of DOI:10.1055/s-2008-1067160

An efficient ligand-free protocol has been developed for the amincocarbonylation of aryl iodides with aromatic/aliphatic amines using palladium(II) acetate as a catalyst in water under milder operating conditions. The system tolerated a wide variety of hindered and functionalized aryl iodides/amines and afforded the desired amides in excellent yields at low catalyst concentration. Georg Thieme Verlag Stuttgart.