Synthesis and evaluation of amide side-chain modified Agomelatine analogues as potential antidepressant-like agents

DOI: 10.1016/j.bmcl.2014.02.065

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Bioorganic and Medicinal Chemistry Letters p. 1672 - 1676 (2014)

Update date:2022-08-03

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Authors:

Chang, Ying

Pi, Weiyi

Ang, Wei

Liu, Yuanyuan

Li, Chunlong

Zheng, Jiajia

Xiong, Li

Yang, Tao

Luo, Youfu

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Article abstract of DOI:10.1016/j.bmcl.2014.02.065

In this work, nineteen analogues of Agomelatine were readily synthesized through structural modification of the acetamide side-chain starting from the key common intermediate 2-(7-methoxynaphthalen-1-yl) ethanamine (3), which was prepared from commerciall

Full text of DOI:10.1016/j.bmcl.2014.02.065

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