A new efficient route to 5-substituted β-2'-deoxyribosylpyrrolo[2,3-d]pyrimidines. Palladium-catalyzed functionalizations of a C-5 triflate intermediate

Article abstract of DOI:10.1021/jo00102a011

An efficient synthesis of a β-2'-deoxyribosyl-5-[(trifluoromethanesulfonyl)oxy]pyrrolo[2,3-d]pyrim idine-2,4-dione 9, starting from 6-chlorouracil, is presented along with its subsequent functionalization at C-5 using four types of palladium-catalyzed reactions.