A useful route to both enantiomers of 1-amino-2-alkanols: Synthesis of 1-amino-3-methyl-2-butanol from valine

Article abstract of DOI:10.1055/s-1994-25657

A multistep synthesis of (S)-1-amino-3-methyl-2-butanol (9) from D-valine (3) is reported. The enantiomeric purity of (S)-9 (97.2 ± 0.2% ee) is determined by GC of the derivative, 5-isopropyloxazolidin-2-one (2) on both L- and D-Chirasil-Val. (R)-9 is pre