ChemCatChem p. 561 - 566 (2014)
Update date:2022-08-05
Topics:
Huang, Liangbin
Wang, Qian
Wu, Wanqing
Jiang, Huanfeng
A convenient and highly efficient synthesis of α-methylene-γ- lactones through the palladium(II)-catalyzed lactonization of homoallylic alcohols with alkynamides has been reported. The hydroxyl group in the terminal olefins cooperates with the amide in alkynamides to promote the cyclization by suppressing the β-H elimination. This process provides a route to construct naturally occurring biologically multifunctional α-methylene-γ- lactones. The time has come to.i?lactonize: α-Methylene- γ-lactones are synthesized through the PdII-catalyzed lactonization of homoallylic alcohols with alkynamides. The hydroxyl group in the terminal olefins cooperates with the amide in alkynamides to promote the cyclization by suppressing the β-H elimination. This provides a route towards naturally occurring biologically multifunctional α-methylene- γ-lactones. Copyright
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Doi:10.1016/S0040-4020(01)89572-7
(1994)Doi:10.1080/00397919508013426
(1995)Doi:10.1016/S0040-4020(01)89357-1
(1994)Doi:10.1021/ol5008845
(2014)Doi:10.1016/j.bmcl.2015.08.048
(2015)Doi:10.5560/ZNB.2012-0087
(2012)