Synthesis of 2'-deoxy-pyranosyl nucleosides from glycals through consecutive addition of phenylselenyl chloride and glycosylation. A study of factors controlling the stereoselectivity

Article abstract of DOI:10.1016/S0040-4020(01)89572-7

2'-Deoxy-2'-phenylselenenyl-pyranosyl nucleosides have been synthesized in a stereoselective way starting from glycals using selenium reagents, and converted into 2'-deoxynucleosides by treatment with tributyltin hydride. The stereoselectivity of the reac