6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5α-Reductase and Human Adrenal 3β-Hydroxy-Δ5-steroid Dehydrogenase/3-Keto-Δ5-steroid Isomerase

DOI: 10.1021/jm00041a014

Source and publish data:

Journal of Medicinal Chemistry p. 2352 - 2360 (1994)

Update date:2022-09-26

Topics:

Authors:

Frye, Stephen V.

Haffner, Curt D.

Maloney, Patrick R.

Mook, Robert A.

Dorsey, George F.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00041a014

6-Azaandrost-4-en-3-ones were synthesized and tested versus human type 1 and 2 steroid 5α-reductase (5AR) and human adrenal 3β-hydroxy-Δ⁵-steroid dehydrogenase/3-keto-Δ⁵-steroid isomerase (3BHSD) to explore the structure-activity rel

Full text of DOI:10.1021/jm00041a014

Products guided by the article

Product name:(1S,3aS,3bS,9aR,9bS,11aS)-1-(2-Cyclohexyl-acetyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,7,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridine-5-carboxylic acid tert-butyl ester

Cas No:160002-04-0

R&D Labs maybe for 160002-04-0

RongCheng Tianyu Technology Co.,Ltd.

Contact:86-631-7519595

Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Shanghai Massive Chemical Technology Co., Ltd.

website:http://www.massivechem.com/

Contact:+86 21 34943721

Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Shandong Yuanli Science and Technology Co., Ltd.

Contact:86-0536-6777557

Address:Zhuliu Industiral Park,Changle County
Taizhou Shengxing Chempharm Co.,Ltd

Contact:+86-576-88516600

Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China
Xiamen Huasing Chemicals Co.Ltd.

Contact:0086-592-6228397

Address:NO.24, Xinglin North 2nd Road,Jimei district

Relevant to this article

Tetrabutylammonium fluoride promoted novel reactions of o- carborane: Inter- and intramolecular additions to aldehydes and ketones and annulation via enals and enones

Doi:10.1021/ja973832e
(1998)
Bicyclic system from acetoacetate ester and 5-amino-1-methyl-, 5-amino-1-benzyl as well as 3(5)-amino-pyrazol

Doi:10.1002/cber.19681010934
(1968)
Influence of the steric properties of pyridine ligands on the structure of complexes containing the {LnCd2(bzo)7} fragment

Doi:10.1007/s11172-020-2934-0
()
Proton switch for modulating oxygen reduction by a copper electrocatalyst embedded in a hybrid bilayer membrane

Doi:10.1038/nmat3974
(2014)
Synthesis of 4-aryl-2-hydroxy-4-oxo-2-butenoic (Aroylpyruvic) acids N-(4-Acetylaminosulfonylphenyl)amides

Doi:10.1134/S1070363214040045
()
A naphthalimide-based bifunctional fluorescent probe for the differential detection of Hg²⁺ and Cu²⁺ in aqueous solution

Doi:10.1039/c4dt00014e
(2014)

Article Doi