6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5α-Reductase and Human Adrenal 3β-Hydroxy-Δ5-steroid Dehydrogenase/3-Keto-Δ5-steroid Isomerase

DOI: 10.1021/jm00041a014

Source and publish data:

Journal of Medicinal Chemistry p. 2352 - 2360 (1994)

Update date:2022-09-26

Topics:

Authors:

Frye, Stephen V.

Haffner, Curt D.

Maloney, Patrick R.

Mook, Robert A.

Dorsey, George F.

et al. et al.

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Article abstract of DOI:10.1021/jm00041a014

6-Azaandrost-4-en-3-ones were synthesized and tested versus human type 1 and 2 steroid 5α-reductase (5AR) and human adrenal 3β-hydroxy-Δ⁵-steroid dehydrogenase/3-keto-Δ⁵-steroid isomerase (3BHSD) to explore the structure-activity rel

Full text of DOI:10.1021/jm00041a014

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