6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5α-Reductase and Human Adrenal 3β-Hydroxy-Δ5-steroid Dehydrogenase/3-Keto-Δ5-steroid Isomerase

DOI: 10.1021/jm00041a014

Source and publish data:

Journal of Medicinal Chemistry p. 2352 - 2360 (1994)

Update date:2022-09-26

Topics:

Authors:

Frye, Stephen V.

Haffner, Curt D.

Maloney, Patrick R.

Mook, Robert A.

Dorsey, George F.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00041a014

6-Azaandrost-4-en-3-ones were synthesized and tested versus human type 1 and 2 steroid 5α-reductase (5AR) and human adrenal 3β-hydroxy-Δ⁵-steroid dehydrogenase/3-keto-Δ⁵-steroid isomerase (3BHSD) to explore the structure-activity rel

Full text of DOI:10.1021/jm00041a014

Products guided by the article

Product name:(1S,3aS,3bS,9aR,9bS,11aS)-1-(2-Cyclohexyl-acetyl)-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,7,8,9,9a,9b,10,11,11a-tetradecahydro-cyclopenta[i]phenanthridine-5-carboxylic acid tert-butyl ester

Cas No:160002-04-0

R&D Labs maybe for 160002-04-0

Hangzhou Neway Chemicals Co., Ltd.

Contact:+86-571-85095566

Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
Zha Yan

Contact:+86-13914766747

Address:Floors 21&22, Jin Cheng Tower, No. 216 Middle Longpan Road, Nanjing
Shanghai birch chemical technology co.,ltd

Contact:+86-21-54096810

Address:No.2588,Jungong Road,Shanghai,China
Kaymossy BioChem Tech Co., Ltd

website:http://www.kaimosi.com

Contact:0571-87191913/0571-87199097

Address:Room 215, Building 3rd, No.288 Ningxia Road, Qingdao city, China
Innua Petrochem Ltd.

Contact:+1-284-4950244

Address:Box 3069, Road Town, Tortola, British Virgin Islands

Relevant to this article

Tetrabutylammonium fluoride promoted novel reactions of o- carborane: Inter- and intramolecular additions to aldehydes and ketones and annulation via enals and enones

Doi:10.1021/ja973832e
(1998)
Bicyclic system from acetoacetate ester and 5-amino-1-methyl-, 5-amino-1-benzyl as well as 3(5)-amino-pyrazol

Doi:10.1002/cber.19681010934
(1968)
Influence of the steric properties of pyridine ligands on the structure of complexes containing the {LnCd2(bzo)7} fragment

Doi:10.1007/s11172-020-2934-0
()
Proton switch for modulating oxygen reduction by a copper electrocatalyst embedded in a hybrid bilayer membrane

Doi:10.1038/nmat3974
(2014)
Synthesis of 4-aryl-2-hydroxy-4-oxo-2-butenoic (Aroylpyruvic) acids N-(4-Acetylaminosulfonylphenyl)amides

Doi:10.1134/S1070363214040045
()
A naphthalimide-based bifunctional fluorescent probe for the differential detection of Hg²⁺ and Cu²⁺ in aqueous solution

Doi:10.1039/c4dt00014e
(2014)

Article Doi