Synthesis of 3-F-alkyl-2-methoxy-3-phenylthiopropenals

DOI: 10.1016/0040-4039(94)85029-1

Source and publish data:

Tetrahedron Letters p. 6877 - 6878 (1994)

Update date:2022-07-30

Topics:

Authors:

Hedhli, Ahmed

Baklouti, Ahmed

Cambon, Aime

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Article abstract of DOI:10.1016/0040-4039(94)85029-1

The synthesis of 3-F-alkyl-2-methoxy-3-phenylthiopropenals has been realised by basic hydrolysis of acetylated sulfides of the type R(F)-CH(OCH₃)-CH(OAc)-S-Ph. A reaction suite is proposed to explain the formation of these aldehydes which may prove useful precursors in synthesis of F-alkylated heterocyclic compounds.

Full text of DOI:10.1016/0040-4039(94)85029-1

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