Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors

DOI: 10.1016/j.bmc.2014.02.030

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Bioorganic and Medicinal Chemistry p. 2535 - 2541 (2014)

Update date:2022-07-30

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Authors:

Yan, Zi-Hong

Huang, Xia-Yun

Wu, Hai-Qiu

Chen, Wen-Xue

He, Qiu-Qin

Chen, Fen-Er

De Clercq, Erik

Pannecouque, Christophe

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Article abstract of DOI:10.1016/j.bmc.2014.02.030

A series of CR₂(OH)-diarylpyrimidine derivatives (CR ₂(OH)-DAPYs) featuring a hydrophobic group at CH(OH) linker between wing I and the central pyrimidine were synthesized and evaluated for their anti-HIV activity in MT-4 cell cultur

Full text of DOI:10.1016/j.bmc.2014.02.030

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