Total synthesis of (+)-tautomycin

Article abstract of DOI:10.1016/0040-4020(96)00811-3

A convergent stereocontrolled total synthesis of (+)-tautomycin (1), a specific inhibitor of protein serine/threonine phosphatases, has been achieved through an esterification of the C₁.-C₇. fragment A'74 with the C₁-C₂₆ fragment B'76 by a modified Yamaguchi method and an aldol reaction of the C₁₇-C₂₆ fragment C 5 with the C₁-C₁₆ fragment D 6 using LDA as key steps. The fragments 5 and 6 have been constructed in a stereocontrolled manner, respectively.