Bioorganic and Medicinal Chemistry Letters p. 1837 - 1842 (1996)
Update date:2022-08-05
Topics:
Golik, Jerzy
Wong, Henry S. L.
Chen, Shu Hui
Doyle, Terrence W.
Wright, J. J. Kim
Knipe, Jay
Rose, William C.
Casazza, Anna Maria
Vyas, Dolatrai. M.
The synthesis, pharmacokinetic properties, and antitumor evaluation of novel paclitaxel phosphonooxymethyl ether derivatives 8-11 and salts thereof is described. These compounds exhibit improved water solubility as compared to paclitaxel (1) and upon incubation with plasma and alkaline phosphatase they readily release parent drug. The in vivo antitumor evaluation of compounds 8-11 established them as suitable pro-drugs of paclitaxel.
View MoreHebei Tianxiang Biological & Pharmaceutical Co., Ltd
Contact:86-0312-6615158
Address:No 42 fazhan street qingyuan county
Tianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Contact:+86-25-52346955
Address:199,JIANYE ROAD,NANJING,CHINA
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.
Contact:86-532-88250866
Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Shanxi Tongji Pharmaceuticals Co., Ltd.
Contact:+86-359-3024784
Address:Xikuang South Road, Ruicheng County , Shanxi
Doi:10.1002/anie.201309791
(2014)Doi:10.1016/j.dyepig.2014.02.023
(2014)Doi:10.1016/S0040-4020(01)89355-8
(1994)Doi:10.1246/bcsj.45.2010
(1972)Doi:10.1002/ardp.19943271011
(1994)Doi:10.1021/jo500478u
(2014)
