Bioorganic and Medicinal Chemistry Letters p. 1837 - 1842 (1996)
Update date:2022-08-05
Topics:
Golik, Jerzy
Wong, Henry S. L.
Chen, Shu Hui
Doyle, Terrence W.
Wright, J. J. Kim
Knipe, Jay
Rose, William C.
Casazza, Anna Maria
Vyas, Dolatrai. M.
The synthesis, pharmacokinetic properties, and antitumor evaluation of novel paclitaxel phosphonooxymethyl ether derivatives 8-11 and salts thereof is described. These compounds exhibit improved water solubility as compared to paclitaxel (1) and upon incubation with plasma and alkaline phosphatase they readily release parent drug. The in vivo antitumor evaluation of compounds 8-11 established them as suitable pro-drugs of paclitaxel.
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