Synthetic Studies on Fully Substituted γ-Pyrone-Containing Natural Products: The First Total Synthesis of Onchitriol II

Article abstract of DOI:10.1016/0040-4039(94)88516-8

The first total synthesis of onchitriol II, a cytotoxic metabolite of mollusc Onchidium sp., is described.It employs mild cyclization method of triketides bearing optically active functional groups to the corresponding γ-py