
Tetrahedron Letters p. 8747 - 8750 (1994)
Update date:2022-08-03
Topics:
Hoye, Thomas R.
Chen, Minzhang
Mi, Liang
Priest, Owen P.
Michellamines A-C have been prepared by total synthesis in 7 and 16 linear steps from known and commercial materials, respectively.Key steps include i) palladium(0)-mediated biaryl coupling, ii) silver oxide promoted oxidative 1-naphthol coupling to an atropisomeric mixture of cross-ring quinones (indigoids), and iii) simultaneous per-debenzylation/reductive bleaching to the central 2,2'-binaphthol.
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