First Access to 3,4-Difluoro-1H-pyrrole

DOI: 10.1016/S0040-4039(00)78448-6

Source and publish data:

Tetrahedron Letters p. 8605 - 8608 (1994)

Update date:2022-08-03

Topics:

Authors:

Leroy, Jacques

Wakselman, Claude

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Article abstract of DOI:10.1016/S0040-4039(00)78448-6

N-Unsubstituted 3,4-difluoropyrrole is synthesized via a thermal <2+3> cycloaddition reaction of a N-tert-butyl 2-alkoxycarbonyl aziridine and chlorotrifluoroethylene.Dealkylation of an intermediate N-tert-butylpyrrole is obtained with trifluoromethanesulfonic acid.

Full text of DOI:10.1016/S0040-4039(00)78448-6

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