First Syntheses of Novel Paclitaxel(Taxol) Analogs Modified at the C4-Position

DOI: 10.1021/jo00100a011

Source and publish data:

Journal of Organic Chemistry p. 6156 - 6158 (1994)

Update date:2022-08-04

Topics:

Authors:

Chen, Shu-Hui

Kadow, John F.

Farina, Vittorio

Fairchild, Craig R.

Johnston, Kathy A.

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Article abstract of DOI:10.1021/jo00100a011

A highly regiospecific method for the modification of paclitaxel at the C-4 position has been invented, as exemplified by the synthesis of the C-4 cyclopropyl ester of paclitaxel (4) and the C-4 benzoate of paclitaxel (5).

Full text of DOI:10.1021/jo00100a011

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