Synthesis of substance-P C-terminal hexapeptide analogues and their biological activity. Analogues with antagonistic activity without containing D-amino acids

Article abstract of DOI:10.1016/0223-5234(94)90028-0

Analogues of the C-terminal hexapeptide of substance P have been synthesized in which each amino-acid residue was replaced by the bulky and strong lipophilic residue Asp(OBzl). The amino-acid residue of other selected places has also been replaced by Glu(