Chemical and Pharmaceutical Bulletin p. 1685 - 1687 (1994)
Update date:2022-07-30
Topics:
Sasaki
A novel DNA cleaving agent, N,N'-bis{2-[4-(3-aminopropylcarbamoyl)-2,4'-bithiazol-2'-yl]ethyl}et hylenediamine (1), was synthesized. At 25 μM concentration, a significant cleaving activity of 1 for plasmid DNA was observed only in the presence of Co(II). Scavengers of active oxygen species could not inhibit the DNA cleavage by 1.
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