Total synthesis of the antitumor natural product polycarcin v and evaluation of its DNA binding profile

Article abstract of DOI:10.1021/ol501095w

The convergent total synthesis of polycarcin V, a gilvocarcin-type natural product that shows significant cytotoxicity with selectivity for nonsmall-cell lung cancer, breast cancer, and melanoma cells, has been achieved in 13 steps from 7, 8, and 22; the