Synthesis of 5-amino-4-sulfonamidoimidazole nucleosides as potential inhibitors of purine nucleotide biosynthesis, and of an imidazothiadiazine dioxide analogue of adenosine

Article abstract of DOI:10.1016/0040-4020(96)00472-3

5-Amino-4-sulfonamido-1-(β-D-ribofuranosyl)imidazole 6 and two more complex sulfonamides, one of which (8) incorporates an L-aspartyl unit, have been prepared as potential inhibitors of the intermediate stages in the pathway for de novo biosynthesis of pu