Lewis acid-promoted alkylations of arenes and 1-trimethylsilylalkynes with β-chloro-β-thiopropanoic esters

DOI: 10.1248/cpb.39.1148

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1148 - 1151 (1991)

Update date:2022-08-05

Topics:

Authors:

Ishibashi

Mino Mino

Sakata Sakata

Inada Inada

Ikeda Ikeda

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Article abstract of DOI:10.1248/cpb.39.1148

Ethyl 3-chloro-3-(3,4-dichlorophenylthio)propanoate (8) reacted with electron-rich arenes in the presence of titanium tetrachloride to give the Friedel-Crafts products 10a-13a. Reactions of 8 with 1-trimethylsilylalkynes 14a-d were effected with aluminum chloride to afford the substitution products 15a-d. Some chemical transformations of the products are also described.

Full text of DOI:10.1248/cpb.39.1148

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