Directed C-H alkenylation of quinoline N-oxides at the C-8 position using a cationic rhodium(I) catalyst

Article abstract of DOI:10.1002/adsc.201400223

The cationic rhodium-catalyzed alkenylation proceeds at the C-8 position of quinoline N-oxides. Regioselective C-H bond activation was achieved by the directing effect of the anionic oxygen of an N-oxide moiety, which can be readily removed by reductive treatment. A variety of 8-alkenylated quinoline N-oxides was obtained in moderate to high yields.