Synthesis of 2'-Deoxynucleosid-3'-yl-N,N-Diisopropylaminophosphorfluoridites. A New Class of Stable PIII Nucleotides Containing a P-F Bond

Article abstract of DOI:10.1016/0040-4039(94)02403-X

A new methodology based on phosphitylating reagents containing 4-nitrophenoxy leaving group has been employed to synthesize stable 5'-O-(4,4'-dimethoxytrityl)nucleosid-3'-yl-N,N-diisopropylaminophosphofluoridites 1a-d.