Direct access to 2-Debenzoyl taxolds by electrochemistry, synthesis of 2-Modified docetaxel analogs

Article abstract of DOI:10.1016/0040-4039(94)88368-8

A new route to semisynthetic 2-modified docetaxel analogs is described using electrochemical cleavage of the 2-benzoate as the key reaction. Subsequent reacylation at C-2 followed by sequential deprotections afforded the title analogs. Biological results