Synthesis of intra-annularly functionalized cationic pyridinophanes

Article abstract of DOI:10.1016/S0040-4020(01)01226-1

The precyclophane 1 derived from 2,6-bis(bromomethyl)pyridine and 2.1 equiv. of benzimidazole afforded pyridinobenzimidazolophanes 6-8 on further reaction with 1 equiv. of 2,6-bis(bromomethyl)pyridine, 3,5-bis(bromomethyl)anisole and 1,3-bis(bromomethyl)-4-nitrophenol, respectively. A similar synthetic strategy was used for the synthesis of pyridinobenzotriazolophanes 9-11. Potential receptors 16 and 17 were also synthesized.