Structure-based design of potent and selective leishmania N -myristoyltransferase inhibitors

DOI: 10.1021/jm5011397

Source and publish data:

Journal of Medicinal Chemistry p. 8664 - 8670 (2014)

Update date:2022-07-29

Topics:

Authors:

Hutton, Jennie A.

Goncalves, Victor

Brannigan, James A.

Paape, Daniel

Wright, Megan H.

Waugh, Thomas M.

Roberts, Shirley M.

Bell, Andrew S.

Wilkinson, Anthony J.

Smith, Deborah F.

Leatherbarrow, Robin J.

Tate, Edward W.

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Article abstract of DOI:10.1021/jm5011397

Inhibitors of Leishmania N-myristoyltransferase (NMT), a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen, were resynthesized to validate activity. Crystal structures bound to Leishmania major NMT were obtained,

Full text of DOI:10.1021/jm5011397

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