Experimental and theoretical analysis of the steric tolerance of the binding site of bacterioopsin with the use of side-chain methyl-shifted retinal analogs

Article abstract of DOI:10.1021/ja00136a021

Four positional isomers of trans-retinal (1) differing in the location of the side-chain methyl groups have been prepared by a combination of Wittig and highly stereocontrolled Suzuki coupling reactions. The incubation of 9-demethyl-10-methylretinal (5) w