A Flexible Approach to Synthetic Lipid Ammonium Salts for Polynucleotide Transfection

DOI: 10.1016/0040-4039(95)00276-I

Source and publish data:

Tetrahedron Letters p. 2207 - 2210 (1995)

Update date:2022-07-29

Topics:

Authors:

Bennett, Michael J.

Malone, Robert W.

Hantz, Michael H.

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Article abstract of DOI:10.1016/0040-4039(95)00276-I

The synthesis of novel 2,3-acyloxy-1-propylammonium salts is described.The route incorporates the use of glycidol and N-methyl-2-aminoethanol to prepare cationic lipids with control of absolute stereochemistry and regioselective introduction of fatty acid side chains.

Full text of DOI:10.1016/0040-4039(95)00276-I

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