An efficient synthesis of a chiral carbocyclic 2'-deoxyribonucleoside synthon by directed reduction

Article abstract of DOI:10.1016/S0040-4039(00)78373-0

Directed reduction of the 1,4 hydroxy-ketone 9 and the 1,4 aldehydo-ketone 12 with NaBH(OAc)₃ gave stereoselectively in high yield the 1,4 diol 10, a key intermediate required in our synthesis of chiral carbocyclic 2'-deoxyribonucleosides