Bioorganic and Medicinal Chemistry p. 715 - 722 (1997)
Update date:2022-08-02
Topics: Synthesis Biological Evaluation Anti-breast cancer agents
Jonnalagadda, Sastry S.
Ter Haar, Ernst
Hamel, Ernest
Lin, Chii M.
Magarian, Robert A.
Day, Billy W.
Z-1,1-Dichloro-2,3-diphenylcyclopropane (1) is an effective anti-breast cancer agent in rodents and in cell culture. We recently determined that 1 inhibits tubulin assembly in vitro, and causes microtubule loss in breast cancer cells, leading to accumulat
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