Synthesis and antitumor activity of pyrrolo[2,3-d]pyrimidine antifolates with a bridge chain containing a nitrogen atom

DOI: 10.1248/cpb.43.256

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 256 - 261 (1995)

Update date:2022-08-02

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Authors:

Aso Aso

Hitaka Hitaka

Yuskishige

Ootsu Ootsu

Akimoto Akimoto

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Article abstract of DOI:10.1248/cpb.43.256

Novel pyrrolo[2,3-d]pyrimidine antifolates (1a, b and 2a, b) with a nitrogen atom in the bridge chain between the 2,4-diaminopyrrolo[2,3-d]pyrimidine and phenylene rings were designed and efficiently synthesized. These compounds exhibited more potent inhi

Full text of DOI:10.1248/cpb.43.256

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