Synthesis and in vitro bronchospasmolytic activity of 8-aryl, heteroaryl or arylalkyl theophyllines

Article abstract of DOI:10.1016/0223-5234(96)88233-X

Twenty-four 8-aryl- or 8-heteroaryl-substituted theophyllines have been synthesized.The substituents are aromatic rings and heterocycles likely to induce an antiallergic effect or a spasmolytic activity.In vitro evaluation of the bronchospasm caused by ac