Synthesis and Biochemical Evaluation of Adenosylspermidine, a Nucleoside-Polyamine Adduct Inhibitor of Spermidine Synthase

DOI: 10.1021/jm00014a023

Source and publish data:

Journal of Medicinal Chemistry p. 2714 - 2727 (1995)

Update date:2022-08-05

Topics:

Authors:

Lakanen, John R.

Pegg, Anthony E.

Coward, James K.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00014a023

The synthesis of a new class of multisubstrate adduct inhibitors of polyamine biosynthesis has been investigated.The first target compound, designed to inhibit spermidine synthase, was obtained and proved to be a very potent inhibitor of that enzyme.Two s

Full text of DOI:10.1021/jm00014a023

Products guided by the article

Product name:2-<2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2-oxazolidinone

Cas No:166193-85-7

R&D Labs maybe for 166193-85-7

Jinan Jianfeng Chemical Co., Ltd

Contact:0086-531-88110457

Address:sales01(-a-t-)pharmachemm{dot}c+o+m
Shanxi Tongji Pharmaceuticals Co., Ltd.

Contact:+86-359-3024784

Address:Xikuang South Road, Ruicheng County , Shanxi
Yingkou Sanzheng Organic Chemical Co. Ltd.

Contact:+86-417-3638818

Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
Chengdu Chengnuo New-Tech Co., Ltd

Contact:0086-028-85749078

Address:4 Jiuyang road,Jiulong industrial port,Chengdu, China

Relevant to this article

Synthesis and characterization of two novel second-order nonlinear optical chromophores based on julolidine donors with excellent electro-optic activity

Doi:10.1039/c6ra21814h
(2016)
Migratory aptitude of the Zr-C functionalities bonded to a macrocyclic structure: Thermally- and solvent-assisted intra- and intermolecular migrations in dialkyl(dibenzotetramethyltetraazaannulene)zirconium(IV)

Doi:10.1021/ja00126a019
(1995)
Reactions of 2-butyne with group 6-group 10 heterobimetallics. New mixed-metal metallacycle chemistry

Doi:10.1021/om00006a044
(1995)
Syntheses of isotopically labeled 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro- 2-naphthyl)ethenyl]benzoic acid (LGD1069), a potent retinoid X receptor-selective ligand

Doi:10.1002/jlcr.2580360712
(1995)
Application of highly stereocontrolled glycosidations employing 2,6-anhydro-2-thio sugars to the syntheses of erythromycin A and olivomycin A trisaccharide

Doi:10.1021/ja00118a008
(1995)
Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels - Alder reactions

Doi:10.1021/ja982078+
(1999)

Article Doi