Synthesis and Biochemical Evaluation of Adenosylspermidine, a Nucleoside-Polyamine Adduct Inhibitor of Spermidine Synthase

DOI: 10.1021/jm00014a023

Source and publish data:

Journal of Medicinal Chemistry p. 2714 - 2727 (1995)

Update date:2022-08-05

Topics:

Authors:

Lakanen, John R.

Pegg, Anthony E.

Coward, James K.

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Article abstract of DOI:10.1021/jm00014a023

The synthesis of a new class of multisubstrate adduct inhibitors of polyamine biosynthesis has been investigated.The first target compound, designed to inhibit spermidine synthase, was obtained and proved to be a very potent inhibitor of that enzyme.Two s

Full text of DOI:10.1021/jm00014a023

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