Design, synthesis, and pharmacological evaluation of dual histamine H2 and gastrin receptor antagonists

Article abstract of DOI:10.1016/S0960-894X(96)00248-X

The joint type of hybrid molecules composed of two pharmacophore moieties taken from histamine H₂ and gastrin receptor antagonists have been designed and synthesized to exhibit dual histamine H₂ and gastrin receptor antagonistic activities. Here we report the importance of spacers as well as binding sites of both pharmacophores for the dual activity.